Final answer:
The liver and kidneys are commonly affected by drug toxicity, but the heart, lungs, and brain can also be impacted by toxic substances.
Step-by-step explanation:
Organs commonly affected by drug toxicity include the kidneys and the liver. The liver is responsible for up to 500 functions, including drug metabolism, which can lead to toxication if the metabolite is more harmful than the precursor. The kidneys play a crucial role in the elimination of toxic waste substances from the blood. In addition to these, other vital organs that can be impacted by toxicity are the heart, the lungs, and the brain. Toxic substances can impede brain cell function and with severe liver damage, these substances can bypass liver filtration and travel directly to the brain. The lungs and skin also contribute to osmoregulation and elimination of wastes through processes like sweating and exhalation.