Final answer:
Ewing Sarcoma is a malignant bone tumor arising from connective tissue cells, primarily affecting children and young adults. It presents with symptoms like pain, fever, and a palpable mass, and is treated through chemotherapy, with surgery or radiation as potential follow-ups.
Step-by-step explanation:
Ewing Sarcoma is a type of malignant bone tumor that arises from mesenchymal (connective tissue) cells. It is a rare disease that most frequently affects children and young adults. Clinical manifestations of Ewing Sarcoma include pain at the tumor site, fever, and a palpable mass. Fractures can occur in affected bones due to weakening from the tumor growth. Additionally, patients may experience anemia, fatigue, and weight loss.
Management of Ewing Sarcoma involves a multidisciplinary approach. Treatment typically includes chemotherapy, which can be followed by surgery or radiation therapy depending on the tumor location and size. Advances in treatment, such as the use of targeted small interfering RNA (siRNA) to knock down tumor growth genes like EWS-FLI1, are also being researched and have shown promise in preclinical models.
The signs, symptoms, and management highlight the necessity for early diagnosis and comprehensive care in improving the prognosis for patients with Ewing Sarcoma.