Final answer:
Macrocytic-Normochromic Anemias feature enlarged RBCs with a normal color, often resulting from vitamin B12 or folate deficiency. Pernicious anemia is an example of this type of anemia. It is distinctly different from iron-deficiency anemia, which shows small, pale RBCs.
Step-by-step explanation:
Macrocytic-Normochromic Anemias are characterized by enlarged red blood cells (RBCs) with adequate hemoglobin concentration, indicating normal color. These anemias are typically caused by faulty or decreased RBC production due to vitamin deficiency, particularly of vitamin B12 or folate. An example of Macrocytic-Normochromic Anemia is pernicious anemia, which is associated with poor absorption of vitamin B12 and can be seen in conditions like Crohn's disease or after certain surgical procedures. In contrast, Iron-deficiency anemia, typically caused by insufficient iron intake or absorption, is characterized by small, pale RBCs (microcytic-hypochromic), while sickle cell anemia and thalassemia involve genetically inherited RBC defects.