Question

Do neonates/infants require higher or lower doses of protein-bound medications? why?

a. Higher, due to increased binding proteins

b. Higher, due to decreased binding proteins

c. Lower, due to increased binding proteins

d. Lower, due to decreased binding proteins

Answer 1

Neonates/infants require lower doses of protein-bound medications due to increased binding proteins in their bloodstream, which affects the effectiveness of the drugs.

Step-by-step explanation:

Neonates/infants require lower doses of protein-bound medications because of increased binding proteins. Binding proteins in the bloodstream have a major impact on the effectiveness of drugs. They can slow drug distribution to the tissues, reduce drug clearance, and cause a loss of drug efficacy. In addition, interactions between drugs are mediated by serum albumin.