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Explain the logic/ rationale for the HIGHER percentage of dysplasia in Erythroplakia (90%) than Leukoplakia (20%):

a. Erythroplakia is more commonly associated with risk factors like tobacco and alcohol use
b. Erythroplakia is typically diagnosed at a later stage than Leukoplakia
c. The vascular nature of erythroplakia makes it more prone to dysplastic changes
d. The specific etiology of erythroplakia makes it more predisposed to dysplasia

User Nymk
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Final answer:

Erythroplakia tends to show a higher percentage of dysplasia compared to leukoplakia due to its biological nature, association with high-risk factors like tobacco and alcohol, and its usual later stage at diagnosis. The red velvety lesions of erythroplakia are more likely to have severe dysplasia or carcinoma in situ due to their vascular nature and mutagen-prone environment.

Step-by-step explanation:

The rationale for the higher percentage of dysplasia in erythroplakia compared to leukoplakia is primarily related to the biological nature of the lesions themselves as well as their association with risk factors. Erythroplakia tends to have a higher rate of dysplastic changes because lesions often present a greater degree of epithelial atypia and cellular abnormalities than lesions of leukoplakia. The specific etiology of erythroplakia includes chronic irritation and trauma, commonly caused by risk factors like tobacco and alcohol use, which can lead to more severe mucosal changes.

Furthermore, erythroplakia's appearance is a red velvety patch that is more likely to exhibit severe dysplasia or an in-situ carcinoma due to the vascular nature of the lesion that makes it prone to acquiring mutagenic changes. The fact that it is usually detected at a later stage also contributes to this higher percentage, as the disease may progress further before being diagnosed. This is unlike leukoplakia, which appears as a white patch and may have a more variable degree of dysplasia, thus having a lower overall percentage when compared to erythroplakia.

User Inkeliz
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