Final answer:
The nurse's assessment question that relates most directly to this patient's hematologic disorder is when did they last have a blood transfusion.
Step-by-step explanation:
The nurse's assessment question that relates most directly to this patient's hematologic disorder is: A) When did you last have a blood transfusion? Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder that affects the red blood cells. This condition increases the susceptibility of red blood cells to oxidative damage, leading to the symptoms of pallor, jaundice, and malaise observed in this patient. Blood transfusions can trigger an acute hemolytic episode in individuals with G6PD deficiency due to the release of oxidative agents, such as medications containing sulfonamides or quinidine. Therefore, knowing the timing of the last blood transfusion is crucial in assessing the potential triggers for the symptoms in this patient.