Final answer:
Substance Abuse refers to the use of any drug or medication for a reason other than which it was intended or in a manner or in quantities other than directed, which can lead to clinically significant impairment or distress.
Step-by-step explanation:
Substance Abuse refers to the use of any drug or medication for a reason other than which it was intended or in a manner or in quantities other than directed, which can lead to clinically significant impairment or distress. It is the misuse of drugs that can have negative consequences.