Final answer:
The expression of concern by the 52-year-old male patient is related to his compromised career goals and retirement plans.
Step-by-step explanation:
The expression of concern by the 52-year-old male patient is related to option C) His career goals and retirement plans are compromised. The patient mentions losing his job due to downsizing, indicating that his career goals are affected. This can lead to feelings of worry and uncertainty about his retirement plans and future prospects.