Final answer:
Tay-Sachs disease is a genetic disorder associated with lysosomes. It is caused by a build-up of sphingolipids in the cells due to a deficiency of an enzyme in the lysosome.
Step-by-step explanation:
Tay-Sachs disease is a genetic disorder that results in the destruction of neurons due to a buildup of sphingolipids in the cells. The organelle that is malfunctioning in Tay-Sachs disease is the lysosome. Lysosomes are responsible for breaking down and digesting unneeded cellular components, but in Tay-Sachs disease, there is a deficiency of an enzyme in the lysosome that leads to the buildup of toxic substances in the cells.