Final answer:
Beta-adrenergic blockers are generally used in combination with other heart failure drugs in patients with heart failure. They work by blocking the beta-receptors in the heart to improve cardiac function. They can also have an effect on the bronchioles of the lungs.
Step-by-step explanation:
Beta-adrenergic blockers are commonly used in patients with heart failure. The accurate statement regarding their use is that they are generally used in combination with other heart failure drugs (option 4). These drugs work by blocking the beta-receptors in the heart, which reduces the workload on the heart and improves cardiac function. The use of higher doses initially or daily dose changes (options 1 and 2) are not accurate regarding the use of beta-adrenergic blockers in heart failure. Additionally, these drugs do have an effect on the bronchioles of the lungs (option 3) and can cause bronchoconstriction in patients with asthma or chronic obstructive pulmonary disease (COPD).