Question

The nurse is reviewing the medications that have been ordered for a patient of whom a loop diuretic has just been prescribed. The loop diuretic may have a possible integration with which of the following?

a. Vitamin D
b. warfarin
c. Penicillins
d. NSAIDs

Answer 1

Loop diuretics such as furosemide inhibit the reabsorption of Na* and Cl- ions and increase urination. NSAIDs may interfere with the diuretic effect of loop diuretics.

Step-by-step explanation:

Loop diuretics such as furosemide (Lasix) are commonly used to treat hypertension. These drugs work by inhibiting the reabsorption of sodium (Na*) and chloride (Cl-) ions in the ascending limb of the loop of Henle in the nephron. One possible interaction of loop diuretics is with nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs can reduce the diuretic effect of loop diuretics by interfering with the prostaglandin-mediated dilation of the afferent arteriole, which would thereby decrease the glomerular filtration rate (GFR) and renal blood flow.