Final answer:
Substances that may interact with isosorbide denitrate (Isordil) include alcohol, tadalafil (Cialis), and carvedilol (Coreg). Thyroid replacement hormones and metformin do not typically interact with Isordil.
Step-by-step explanation:
The nurse is reviewing drug interactions with a male patient who has a prescription for isosorbide denitrate (Isordil) as treatment for angina symptoms. The substances that could potentially result in a drug interaction are:
- A glass of wine: Alcohol can increase the vasodilatory effects of nitrates, which can lead to severe hypotension and cardiovascular complications.
- tadalafil (Cialis), an erectile dysfunction drug: Phosphodiesterase inhibitors can also lead to severe hypotension when combined with nitrates, as they both have vasodilating properties.
- carvedilol (Coreg), a beta blocker: While beta blockers are often used in cardiac patients, they need to be carefully managed when used in conjunction with vasodilators like Isordil due to the potential for increased effects on heart rate and blood pressure.
Thyroid replacement hormone and metformin (Glucophage), an antidiabetic drug, are not typically known for having direct interactions with nitrates like Isordil, but always consult a healthcare provider for comprehensive drug interaction advice.