Final answer:
Hirschsprung disease results from defects in the migration of neural crest cells, leading to a lack of ganglion cells in the intestines.
Step-by-step explanation:
Defects in migration of neural crest cells result in various developmental disorders. One specific condition caused by such defects is Hirschsprung disease, where neural crest cells fail to migrate properly during embryonic development. This leads to a lack of ganglion cells in the intestinal tract, particularly the colon, causing issues with bowel movements and potential intestinal obstruction.
Neural crest cells are essential for the proper formation of the peripheral nervous system and other structures. They originate from the border between the neural plate and the non-neural ectoderm and migrate to different parts of the body during embryogenesis. When these cells do not reach their intended destinations or fail to differentiate properly, it can lead to a variety of structural and functional abnormalities.