Final answer:
The clinical validity of a genetic screen is determined by the false positive rate, false negative rate, positive predictive value, and negative predictive value, hence the answer is E. All of the above.
Step-by-step explanation:
The clinical validity of a genetic screen is determined by several factors, which include the false positive rate, false negative rate, positive predictive value, and negative predictive value. Therefore, the correct answer to the question of which factors determine the clinical validity of a genetic screen is E. All of the above.
Explaining further, the false positive rate indicates the frequency with which individuals who do not have the condition in question incorrectly test positive. False negative rate indicates how often the screen fails to detect the condition in those who actually have it. Positive predictive value represents the probability that individuals with a positive test result actually have the condition, while negative predictive value represents the likelihood that individuals with a negative test result truly do not have the condition.
Accurate genetic screening is vital for appropriate clinical decisions, where minimizing both false positives and false negatives is crucial for patient care and treatment strategies.