Final answer:
Tonicity is crucial for stability, especially in ophthalmic or nasal applications of pH-sensitive dosage forms. Matching the tonicity of the dosage form with that of the body fluid is important to prevent adverse effects. Proper tonicity helps maintain stability and ensure the safety of the application.
Step-by-step explanation:
In the development of dosage forms for pH-sensitive body fluids, tonicity is crucial for stability, especially in ophthalmic or nasal applications. Tonicity refers to the osmotic pressure of a solution and it is important to match the tonicity of the dosage form with that of the body fluid to prevent any adverse effects such as cell membrane damage or irritation.
For ophthalmic applications, the pH and tonicity of the eye drops or ointments must be carefully controlled to ensure compatibility with the tear film. Nasal applications also require formulations that are isotonic with nasal mucosa to minimize discomfort or damage to the nasal tissue.
Overall, maintaining proper tonicity in pH-sensitive dosage forms is crucial for stability and the safety of the application.