Final answer:
The nurse should acknowledge the patient's concerns and ask about her coping strategies.
Step-by-step explanation:
The nurse should respond by acknowledging the patient's concerns and empathizing with her. Option c, "This must be difficult for you. Tell me how you are coping with these changes.", is the most appropriate response in this situation. The nurse should validate the patient's feelings and open up a conversation about her coping strategies. This response shows compassion and gives the patient an opportunity to discuss her concerns further.