Final answer:
The disease of the small intestine would have the greatest effect on absorption of nutrients.
Step-by-step explanation:
The disease of the small intestine would have the greatest effect on absorption of nutrients. The small intestine is the primary site of nutrient absorption in the digestive system. It has a large surface area due to the presence of finger-like projections called villi, which increase absorption efficiency. If the small intestine is diseased or damaged, it can impair the absorption of nutrients, leading to nutritional deficiencies.