Final answer:
Korsakoff syndrome is a chronic memory disorder caused by severe deficiency of thiamine (vitamin B-1), often due to alcohol misuse. It is characterized by memory loss and confabulation.
Step-by-step explanation:
The chronic memory disorder caused by severe deficiency of thiamine (vitamin B-1), often due to alcohol misuse, is called Korsakoff syndrome. This condition is characterized by memory loss, especially of recent events, and confabulation, which is the production of fabricated or distorted memories. It is commonly associated with long-term alcohol abuse.