Final answer:
Selective serotonin reuptake inhibitors (SSRIs) are the best anti-depressants with least side effects and drug interactions.
Step-by-step explanation:
The best anti-depressants in terms of least side effects and interaction with other drugs are selective serotonin reuptake inhibitors (SSRIs). SSRIs, such as Prozac, Paxil, and Zoloft, work by preventing the reuptake of serotonin, thereby increasing its effectiveness in the brain. These medications have been found to have fewer side effects compared to other anti-depressant classes, such as benzodiazepines, opioids, and antipsychotics.