Final answer:
The patient most likely to experience anemia related to increased destruction of red blood cells is a 23-yr-old African American man with sickle cell disease.
Step-by-step explanation:
The patient most likely to experience anemia related to an increased destruction of red blood cells is Option B: A 23-yr-old African American man who has a diagnosis of sickle cell disease.
Sickle cell disease is an inherited condition that causes red blood cells to become rigid and sickle-shaped, leading to their destruction. The physiological changes observed in sickle cell anemia are physical exertion, weakness, shortness of breath, and anemia.
While options A, C, and D can also cause anemia, they are not directly related to increased destruction of red blood cells.