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A colleague with myasthenia gravis wants you to assist him to the ER because he is experiencing muscle weakness and has found it difficult to titrate his drug dosage because he has had the flu. You note that he has a slight temperature, shallow respirations, and a gray-blue skin pallor. What would be the most appropriate drug to give to your colleague at this time?

A. Albuterol
B. Edrophonium
C. Propranolol
D. Physostigmine
E. Scopolamine

User Behroozbc
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1 Answer

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Final answer:

The most suitable course of action for the colleague with myasthenia gravis experiencing a potential myasthenic crisis is to get immediate emergency medical treatment. Drugs like Edrophonium and Physostigmine are acetylcholinesterase inhibitors that may be used in a hospital setting but are not suitable for emergency administration by non-medical personnel.

Step-by-step explanation:

In the scenario presented, a colleague with myasthenia gravis is experiencing muscle weakness and requires immediate medical attention. Myasthenia gravis is an autoimmune disorder where antibodies block acetylcholine receptors at the neuromuscular junction, causing muscle weakness. Given the symptoms of shallow respirations and a grey-blue skin pallor, the colleague is likely experiencing a myasthenic crisis, which is a life-threatening condition that requires immediate treatment.

Among the options provided:

Edrophonium (B) is a short-acting acetylcholinesterase inhibitor used diagnostically for myasthenia gravis due to its ability to temporarily improve muscle strength. However, it is not the most appropriate in an emergency context where the patient's respiratory function is compromised.Physostigmine (D), another acetylcholinesterase inhibitor with a longer duration of action than Edrophonium, can cross the blood-brain barrier and could be used to treat both central and peripheral anticholinergic symptoms, making it a possible candidate for treatment.

Considering the life-threatening nature of the symptoms described, emergency respiratory support is the immediate concern, and drugs that treat the underlying cause of muscle weakness in myasthenia gravis would be secondary and should be administered under medical supervision in a hospital setting. Therefore, neither of the drugs provided in the options would be suitable for immediate administration by a non-medical professional outside of the ER. The most appropriate action would be to assist the colleague in getting emergency medical treatment.

User Sashaegorov
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