Final answer:
Stress reduction techniques are the most direct method for reducing elevated cortisol levels due to stress. They aim to decrease the body's stress response. Antidepressants and beta-blockers have different primary targets but may indirectly affect cortisol levels.
Step-by-step explanation:
The question addresses the issue of elevated cortisol levels as a result of chronic stress and its relationship to depression, particularly major depressive disorder (MDD). Cortisol is a hormone released by the adrenal glands in response to stress and affects several body functions. The therapy option that would most directly aim to reduce elevated cortisol levels due to higher rates of agnostic interactions would be stress reduction techniques. These techniques work by mitigating the stress response, thus potentially decreasing cortisol production. Other options like antidepressant medication, while they can address symptoms of depression and may indirectly affect cortisol levels by improving depressive symptoms, are not primarily focused on reducing cortisol levels. Similarly, beta-blocker administration is more commonly associated with cardiovascular issues like high blood pressure and is not directly aimed at cortisol reduction. Thyroid hormone therapy is irrelevant to cortisol levels and is mainly used for thyroid hormone imbalances.