Question

Claudin that causes mice to die from dehydration from uncontrolled water loss

(A) Claudin-5
(B) Claudin-8
(C) Claudin-15
(D) Claudin-19

Answer 1

Arsenic poisoning can disrupt Cl- ion transport in epithelial cells, leading to dehydrated mucus similar to CF.

Step-by-step explanation:

Arsenic poisoning can disrupt ATP production, leading to decreased transport of Cl- ions by epithelial cells. This can result in decreased electrolyte concentration in the mucus and retention of water into the cells. As a result, the mucus becomes dehydrated, similar to the condition seen in cystic fibrosis (CF).