Final answer:
Vaccine administration can sometimes cause a decrease in anti-rhinovirus antibodies due to a phenomenon where a vaccine suppresses specific antibodies, this can occur through original antigenic sin if there is cross-reactivity between the viral antigens of the vaccination and subsequent infections.
Step-by-step explanation:
The correct answer to the question of what would cause a decrease in anti-rhinovirus antibodies is D) Vaccine administration. While vaccines generally stimulate the immune system to produce antibodies, in some cases, a phenomenon known as original antigenic sin can occur, where a vaccine suppresses antibodies in the person's body that were specific to a particular virus. This suppression can happen if the flu virus that subsequently infects the person is similar enough for cross-reactivity to occur between the virus antigens causing the infection and the antigens in the vaccine.
Vaccines such as the influenza vaccine are designed this way: Weakened influenza virions are administrated nasally and can replicate in the colder temperatures of the nasal passages, inducing a protective adaptive immune response without causing serious flu symptoms. However, vaccines for the common cold are not typically administered because there are many different viruses that can cause it, and it's difficult to develop immunity to all of them.