Question

Non-fibrillar collagen-based disease: Type IV

Fibril collagen-based disease: Fibrosis
What are some disease states associated with matrix metalloproteinases (MMPs)?
(A) Rheumatoid arthritis
(B) Osteoporosis
(C) Alzheimer's disease
(D) Type 2 diabetes

Answer 1

Matrix metalloproteinases (MMPs) are enzymes involved in ECM breakdown. Disease states associated with MMPs include rheumatoid arthritis, Alzheimer's disease, and type 2 diabetes.

Step-by-step explanation:

Matrix metalloproteinases (MMPs) are enzymes involved in the breakdown and remodeling of the extracellular matrix (ECM). Some disease states associated with MMPs include:

• Rheumatoid arthritis: MMPs contribute to the destruction of joint tissues in this autoimmune disease.
• Alzheimer's disease: MMPs are involved in the degradation of the amyloid beta plaques that are characteristic of this neurodegenerative disorder.
• Type 2 diabetes: MMPs play a role in the development of diabetic complications, such as diabetic retinopathy.