Final answer:
Increased U incorporation can lead to mutation.
Step-by-step explanation:
Increased U incorporation can lead to increased attempted repair which can then lead to mutation. When DNA is damaged, cells have mechanisms in place to repair the damage. However, if the damage is not repaired correctly, it can result in changes to the DNA sequence, which are known as mutations. These mutations can have various consequences, including the development of diseases such as cancer or genetic disorders.