Final answer:
The statement is false; each TCR is highly specific and can only bind with one specific antigenic epitope. TCRs are generated through gene recombination, leading to a vast diversity of TCRs, each recognizing a unique antigen-MHC complex.
Step-by-step explanation:
The statement that 'One TCR can bind to different antigens' is false. T-cell receptors (TCRs) are highly specific to the antigen they recognize. Each TCR consists of two peptide chains (alpha and beta) and is generated by the recombination of genes specific to each TCR, resulting in millions of unique TCRs. This diversity is crucial as TCRs recognize processed antigen peptides presented by Major Histocompatibility Complex (MHC) molecules on antigen-presenting cells. The unique structure of each TCR allows it to bind specifically to a certain antigen-MHC complex, with thousands of identical TCRs present on a single T cell's surface. This specific recognition is what triggers the appropriate immune response by the adaptive immune system against the invading pathogen.
While each TCR can only bind with one specific antigenic epitope, a protein antigen can have multiple antigenic determinants, which means that different TCRs on different T cells can recognize different parts of the same protein antigen. This is distinctly different from B-cell receptors, which do not require MHC presentation and can bind free antigens and recognize different molecular classes including proteins, polysaccharides, and lipopolysaccharides.