Question

Which of the following contribute to normal Resting Membrane Potential (RMP) in excitable tissues?

Large Intracellular Anionic Proteins
K "leak" channels
Voltage-Gated Ca^2+ channels
K^+ diffusion gradient
Na^+ diffusing INTO cells
Na^+/K^+ Pump
a) 1, 2, 3
b) 2, 4, 6
c) 3, 5, 6
d) 1, 4, 5

Answer 1

The normal Resting Membrane Potential (RMP) in excitable tissues is maintained by Large Intracellular Anionic Proteins, K "leak" channels, and the Na+/K+ Pump, with option b) 2, 4, 6 being the correct factors that contribute to RMP.

Step-by-step explanation:

The factors that contribute to the normal Resting Membrane Potential (RMP) in excitable tissues include Large Intracellular Anionic Proteins, K "leak" channels, and the Na+/K+ Pump. Voltage-gated Ca2+ channels are not typically involved in maintaining the RMP but rather in changing the membrane potential during action potentials. Na+ diffusing into cells partially counteracts the RMP, but the Na+/K+ pump works to pump Na+ out which helps maintain RMP. The K+ diffusion gradient, created by a higher concentration of K+ inside the cell compared to outside, promotes K+ efflux out of the cell, thus contributing to RMP. Therefore, the correct answer is that 1, 2, and 6 contribute to RMP, making option b) the correct choice.