Final answer:
The correct answer is tolerance, which is the need to increase drug doses over time to achieve the same effect.
Step-by-step explanation:
The need to progressively increase the dose of a drug to reproduce the effect originally achieved at smaller doses is referred to as tolerance. This physiological condition means that over time, the body adapts to the drug, diminishing its effects, and requires larger quantities to achieve the initial effect. It is different from addiction, which is the compulsive use of a substance despite negative consequences, and substance abuse, which is the use of a substance without medical advice or beyond its intended purpose. Withdrawal refers to the symptoms experienced when a user stops taking a drug, and reuptake is a process affecting neurotransmitter activity in the brain, not directly related to the question.