Final answer:
Withdrawal from chronic use of high doses of marijuana can cause physical signs such as agitation, anxiety, sleep problems, nausea and vomiting, as well as muscular problems due to the body's readjustment to the absence of the substance.
Step-by-step explanation:
Withdrawal from chronic use of high doses of marijuana can lead to various physical signs, such as agitation, anxiety, sleep problems, nausea and vomiting, abnormal heart rhythms, low blood pressure, and muscular problems. These symptoms are the result of the body's attempt to readjust after becoming accustomed to the presence of the substance. When someone develops a drug dependence, their body and brain may operate differently in its absence, leading to discomfort and various withdrawal symptoms.
Additionally, the cessation of drug use after developing a physical dependence can manifest with various withdrawal symptoms which further reflect the complex nature of addiction and dependence. Addiction, dependence, and rehabilitation are important concepts in understanding the impact of long-term substance use and the process required for recovery.