Question

Which type of P-type ATPase would you expect to find is defective in a novel cell line in which you observe that maintenance of the phospholipid asymmetry in the plasma membrane is impaired?

A) type 1
B) type 2
C) type 3
D) type 4
E) type 5

Answer 1

Defects in D) type 4 P-type ATPases, or flippases, would likely result in impaired phospholipid asymmetry in the plasma membrane of a cell line.

Step-by-step explanation:

The type of P-type ATPase that you would expect to find defective in a novel cell line where the maintenance of phospholipid asymmetry in the plasma membrane is impaired would be type 4 (D) ATPase. These are also known as flippases, and they play a crucial role in maintaining the asymmetry of phospholipids by flipping them from one leaflet of the bilayer to the other. A defect in these ATPases would lead to a loss of membrane asymmetry, impacting various cellular functions including membrane fluidity, vesicle formation, and cell signaling.