Final answer:
The diagnosis of multiple myeloma depends on the detection of Bence Jones proteins in the urine and elevated levels of monoclonal immunoglobulins, or M proteins, in the blood, which is identified using immunoelectrophoretic.
Step-by-step explanation:
The diagnosis of multiple myeloma (MM) largely depends on a few key factors:
- Presence of more than 10% plasma cells in the bone marrow, although this factor is not mentioned in the information provided.
- Bence Jones protein excretion, which occurs in multiple myeloma as well as other plasma cell disorders. These proteins can be detected in the urine, and their presence is indicative of disease.
- Elevated levels of a certain type of abnormal immunoglobulin, or M protein, in the blood. Immunoelectrophoretic (IEP) is used to identify these monoclonal proteins and is useful in establishing a diagnosis.
Among the options presented in the question, the excretion of Bence Jones protein and the increase in M protein (not albumin) concentration are relevant to the diagnosis of MM. Decreased concentrations of B Lymphocytes and increased albumin concentration in serum protein are not standard diagnostic criteria for multiple myeloma.