Final answer:
The federal government has exclusive authority to regulate commerce that substantially affects trade among the states.
Step-by-step explanation:
The statement is true. The federal government does have exclusive authority to regulate commerce that substantially affects trade among the states. This authority comes from the Commerce Clause of the U.S. Constitution, which grants Congress the power to regulate interstate commerce. This means that the federal government can pass laws and regulations to govern trade and economic activities that cross state lines.