Final answer:
The major components of the ECM in connective tissue are collagens, proteoglycans, and glycoproteins.
Step-by-step explanation:
The major components of the extracellular matrix (ECM) in connective tissue are:
- Collagens: These are the major component of ECM, constituting 25% of all proteins in mammals. They are distributed in various tissues such as skin, bone, tendon, blood vessels, cornea, cartilage, intervertebral discs, and vitreous body as fibril-forming. They are also present in basement membranes and beneath squamous epithelium as a network-forming.
- Proteoglycans: These are carbohydrate-containing protein molecules that are interwoven with collagen fibers. They contribute to the structure and organization of the ECM by trapping water molecules, providing hydration and compressibility to the tissue.
- Glycoproteins: These are proteins that have carbohydrate chains attached to them. They play a role in cell adhesion, migration, and communication within the ECM.