Question

What are the two processes involved in AMPA receptors in LTP?

Answer 1

The two processes involved in AMPA receptors in long-term potentiation (LTP) are the insertion of AMPA receptors and the removal of AMPA receptors in long-term depression (LTD).

Step-by-step explanation:

The two processes involved in AMPA receptors in long-term potentiation (LTP) are:

1. Insertion of AMPA receptors: During LTP, a signaling cascade is initiated by calcium entry through NMDA receptors. This cascade leads to the insertion of more AMPA receptors into the postsynaptic membrane. The increased number of AMPA receptors allows for a stronger response to glutamate release, resulting in a potentiated synapse.
2. Removal of AMPA receptors: In long-term depression (LTD), a different signaling cascade is triggered by calcium entry through NMDA receptors with a low firing rate of the presynaptic neuron. This cascade leads to the endocytosis and removal of AMPA receptors from the postsynaptic membrane. The decrease in AMPA receptors weakens the synapse and makes the postsynaptic neuron less responsive to glutamate.