Final answer:
RNA's function is closely tied to its three-dimensional structure, and Otis's project shows that even small changes in the base pair sequence can lead to different RNA structures and functions.
Step-by-step explanation:
The principle of RNA most reflected through Otis's genomics project is that RNA's degree of function will vary based on the structure it takes on. This principle highlights how a small base pair differentiation can alter RNA secondary structures, thereby affecting its function. RNA molecules are able to fold into complex three-dimensional structures due to extensive intramolecular base pairing, which is crucial for their function as catalysts and genetic information carriers.
Different secondary structures in RNA can arise from minor sequence variations. These structures are not simply determined by base pairing, but also by how the entire molecule folds and interacts with its environment, possibly affecting the molecule's role in processes such as protein synthesis. Thus, small changes in the nucleotide sequence can have a considerable impact on the RNA molecule's overall structure and its subsequent biological function.