Final answer:
The true statement about intrinsic factor is that it is secreted by parietal cells and is necessary for the absorption of vitamin B12 in the small intestine.
Step-by-step explanation:
The intrinsic factor is a crucial glycoprotein necessary for the absorption of vitamin B12 in the small intestine. It is secreted by parietal cells located in the gastric glands of the stomach. Intrinsic factor is not related to vitamin D, is not produced by the pancreas, is not a hormone, and hyper secretion of intrinsic factor does not lead to anemia, but rather, a deficiency can contribute to pernicious anemia due to impaired absorption of vitamin B12.