Final answer:
Negative sense RNA genomes are replicated into positive sense RNA genomes by viral RNA-dependent RNA polymerase. Positive sense DNA viruses convert their RNA genomes into DNA using reverse transcriptase.
Step-by-step explanation:
If a virus has a negative sense RNA genome, it needs to go through a replication process to generate a positive sense RNA genome that can be translated by host ribosomes. This replication is carried out by viral RNA-dependent RNA polymerase (RdRP), which uses the negative strand as a template to create a positive sense RNA strand. The newly synthesized positive sense RNA can then be translated into viral proteins.
For positive sense DNA viruses, the replication process involves the conversion of viral RNA genome into DNA by an enzyme called reverse transcriptase. The viral DNA is then incorporated into the host genome, and mRNA is transcribed from the integrated DNA for translation into viral proteins.