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What are the physiologic roles of IGF-1?

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Final answer:

IGF-1, stimulated by Human Growth Hormone, has crucial roles in bone and muscle development, enhances amino acid uptake for protein synthesis, supports liver function, and contributes to metabolic rate regulation.

Step-by-step explanation:

The physiologic roles of Insulin-like Growth Factor 1 (IGF-1) are multifaceted and critically important for normal human development and growth. IGF-1, which is stimulated by Human Growth Hormone (GH), plays a significant role in the development of bones and muscles. It acts on skeletal muscle and bone tissues, where it accelerates protein synthesis, aiding in the growth of these tissues. IGF-1 promotes the uptake of amino acids into cells, facilitating the production of new proteins and supporting muscle and bone growth. Additionally, IGF-1 is vital for the proper functioning of the liver, where it contributes to its growth-promoting effects. It also has a metabolic role in stimulating a higher metabolic rate, balancing energy levels in the body.

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