Final answer:
CRH and ADH release are governed by negative feedback mechanisms in response to physiological changes. CRH regulates the stress response and ADH controls water retention. Their release is modulated by the levels of hormones in the blood and other stimuli.
Step-by-step explanation:
The synthesis and release of corticotropin-releasing hormone (CRH) and antidiuretic hormone (ADH) are tightly regulated by feedback mechanisms in response to various physiological conditions. CRH is a key hormone in the hypothalamic-pituitary-adrenal (HPA) axis and plays an essential role in the body's response to stress. It stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH), which then prompts the secretion of corticosteroids, such as glucocorticoids from the adrenal cortex.
ADH, also known as vasopressin, is vital for water balance and is released from the posterior pituitary gland when osmoreceptors in the hypothalamus detect an increase in blood plasma concentration. This hormone travels to the kidneys and alters their permeability to water, facilitating water reabsorption. As water is conserved, the blood osmolarity is reduced, which then decreases the secretion of ADH through a negative feedback mechanism.