Final answer:
Macbeth and his wife plan to murder King Duncan and frame his guards for the crime in order to make the witches' predictions come true.
Step-by-step explanation:
To make the witches' predictions come true, Macbeth and his wife plan to take action. Specifically, they plot to murder King Duncan and frame his guards for the crime. Lady Macbeth suggests that they will drug the guards with wine and persuade them to commit the murder while they are in a state of deep sleep. By doing so, Macbeth and his wife aim to manipulate the circumstances and fulfill the prophecies.