Final answer:
The drug of choice for treating IBS when pain is the predominant symptom is generally not NSAIDs but could include COX-2 selective inhibitors like Celebrex (celecoxib). Soluble fiber supplements also play a role in managing IBS symptoms. Opioids are reserved for severe cases and require doctor's supervision.
Step-by-step explanation:
When considering the treatment of Irritable Bowel Syndrome (IBS) with predominant pain symptoms, it is important to understand the nature of the pain and the different types of medications available. Aspirin and other NSAIDs, which work by blocking COX enzymes involved in inflammation, are generally effective for pain of low-to-moderate intensity associated with inflammation. However, they are not typically effective for pain arising from the hollow viscera, which includes IBS.
For treating IBS pain, medicines that target the neurotransmitter serotonin may be considered because of its role in the gastrointestinal tract and association with well-being. Additionally, COX-2 selective inhibitors such as Celebrex (celecoxib) might be an option since they specifically inhibit the COX-2 enzyme involved in inflammation, potentially reducing gastrointestinal adverse effects compared to non-selective NSAIDs.
However, if over-the-counter medicines are ineffective, a doctor may prescribe stronger medications, including opioids which must be used under strict supervision due to the risks of side effects, addiction, and overdose. Meanwhile, dietary modifications through increased intake of soluble fiber supplements may alleviate some IBS symptoms by improving overall digestive health.