Question

53 yo pt presents with cough, bloody sputum, and a urine analysis indicating glomerulonephritis. - The palpable purpura on examination and the skin biopsy findings are indicative of a small-vessel vasculitis. - In the absence of granuloma formation, __1__ is the most likely diagnosis. 2). What antibodies are positive in 90% of pts with this? 3). A kidney biopsy would show what?

Answer 1

The most likely diagnosis for the patient described is ANCA-associated vasculitis. ANCA antibodies are present in about 90% of these cases. Kidney biopsy findings usually reveal necrotizing glomerulonephritis.

Step-by-step explanation:

A 53-year-old patient presenting with cough, bloody sputum, and glomerulonephritis, alongside the findings of palpable purpura and a skin biopsy consistent with small-vessel vasculitis and without granuloma formation, is most likely diagnosed with ANCA-associated vasculitis.

2). Antibodies that are positive in 90% of patients with this disease are ANCA (antineutrophil cytoplasmic antibodies).

3). A kidney biopsy in patients with this condition would typically show necrotizing glomerulonephritis, without immune complex deposition.