Question

How are primary aliphatic amines prepared by the reaction of ammonia with halogenoalkanes?

A) Dehydration of alcohols
B) Oxidation of aldehydes
C) Nucleophilic substitution
D) Reduction of carboxylic acids

Answer 1

Primary aliphatic amines are prepared by the reaction of ammonia with halogenoalkanes through nucleophilic substitution.

Step-by-step explanation:

Primary aliphatic amines are prepared by the reaction of ammonia with halogenoalkanes through nucleophilic substitution.

The reaction steps involve:

Nucleophilic attack of the nucleophilic amino moiety to the electrophilic carbo-nyl carbon

Deprotonation of the positive nitrogen atom and protonation of the negative oxygen atom

Elimination of water by protonation of the hydroxyl group and deprotonation at the nitrogen atom

This process is called nucleophilic substitution and allows for the synthesis of primary aliphatic amines.