Final answer:
The significant virulence factor for Clostridium perfringens is Alpha-toxin.
Step-by-step explanation:
The significant virulence factor for Clostridium perfringens is Alpha-toxin. It is one of the protein toxins produced by this bacterium. Alpha-toxin is involved in causing tissue damage and can result in the death of tissue. It is responsible for the pathogenesis of conditions like gas gangrene.