Final answer:
Dihydrotestosterone (DHT) is the primary hormone responsible for androgen stimulation in tissues like skin and hair follicles, being a more potent androgen than its precursor testosterone.
Step-by-step explanation:
The hormone most responsible for the clinical expression of androgen stimulation in androgen-sensitive tissues, such as skin and hair follicles, is dihydrotestosterone (DHT). Testosterone, produced in the testes by Leydig cells, is converted to DHT by the enzyme 5-alpha-reductase. While testosterone is responsible for facilitating puberty changes like muscle growth and voice deepening, it's DHT that exerts stronger effects on the skin, prostate, and hair, leading to characteristic features of male secondary sexual characteristics. Despite DHEA being an androgen produced by the adrenal cortex, and testosterone and reductase playing roles in androgenic activity, it is DHT that ultimately serves as the most potent androgen in the target tissues.