Question

Name the 3(-4) enzymes involved in glycogenolysis

Answer 1

Glycogenolysis is the process of breaking down glycogen to glucose, involving three main enzymes: Glycogen phosphorylase, Debranching enzyme (amylo-1,6-glycosidase), and Phosphoglucomutase. These enzymes work together to release glucose from glycogen stores, particularly during high energy demands.

Step-by-step explanation:

The breakdown of glycogen to glucose is known as glycogenolysis. Three key enzymes are involved in this process:

1. Glycogen phosphorylase - This is the primary enzyme that catalyzes the release of glucose units from the linear chain of glycogen by acting on α-1→4 glycosidic linkages.
2. Debranching enzyme (amylo-1,6-glycosidase) - This enzyme acts on the α-1→6 glycosidic linkages, which are found at the branch points in glycogen. It helps in releasing free glucose by breaking these linkages.
3. Phosphoglucomutase - After glycogen phosphorylase has done its work, phosphoglucomutase converts glucose-1-phosphate to glucose-6-phosphate, which can then enter glycolysis or be converted to free glucose in the liver.

The mechanism of glycogenolysis involves sequential enzymatic reactions that ultimately provide free glucose or glucose-1-phosphate from the stored form of glycogen within the liver and muscle cells. This process is crucial, especially during the fight-or-flight response, to supply the body with quick energy.