Question

What is the MOA of ACE inhibitors?

A. They work by connecting A to C and then to E
B. They work by inhibiting bacterial cell wall synthesis
C. They work by preventing the attachment of A2 to receptor sites
D. They work by inhibiting the conversion of angiotensin 1 to angiotensin 2

Answer 1

ACE inhibitors work by inhibiting the conversion of angiotensin I into angiotensin II, leading to lower blood pressure by preventing vasoconstriction and reducing levels of hormones that cause water and sodium retention.

Step-by-step explanation:

The mechanism of action (MOA) of ACE inhibitors is to block the conversion of angiotensin I to angiotensin II. Angiotensin I is an inactive molecule that is converted into the active molecule angiotensin II by the angiotensin-converting enzyme (ACE), an enzyme primarily found in the lungs. Angiotensin II plays a crucial role in the regulation of blood pressure by causing blood vessels to narrow (vasoconstriction). When ACE inhibitors impede the conversion of angiotensin I to angiotensin II, they effectively lower blood pressure by preventing this vasoconstriction. Additionally, angiotensin II stimulates the release of aldosterone and antidiuretic hormone (ADH), which increase blood pressure by causing the body to retain sodium and water. By inhibiting the production of angiotensin II, ACE inhibitors reduce the levels of aldosterone and ADH, contributing to a decrease in blood pressure.