Final answer:
Spironolactone (option A) is the medication that increases the effect of Potassium Chloride as it helps retain potassium in the body, contrary to loop diuretics like Furosemide, Torsemide, and Bumetanide, which promote potassium excretion.
Step-by-step explanation:
When answering the question, which of the following medications increases the effect of Potassium Chloride? Among the options provided: A. Spironolactone; B. Furosemide; C. Torsemide; and D. Bumetanide, the correct answer is A. Spironolactone. Spironolactone is a potassium-sparing diuretic which means that it helps your body retain potassium while still diuresing. Loop diuretics like Furosemide, Torsemide, and Bumetanide (as described in the second, third, and fourth options), on the other hand, actually promote the excretion of potassium, which could decrease potassium levels in the body.
Loop diuretics inhibit the reabsorption of sodium (Na+) and chloride (Cl−) ions in the ascending limb of the loop of Henle, increasing urine output. Spironolactone works differently by conserving potassium due to its interference with the hormone aldosterone, which is responsible for the excretion of potassium and reabsorption of sodium. Therefore, patients on Spironolactone typically see an increase in the effect of Potassium Chloride as both the medication and Potassium Chloride act to increase potassium levels.