Final answer:
The item in "The Binding of Isaac" that grants the effect "Toxic Blood" is Anemic.
Step-by-step explanation:
The item in "The Binding of Isaac" that grants the effect "Toxic Blood" is A) Anemic. Anemic gives Isaac 5 Range Up and causes him to leave a trail of blood creep behind him when he takes damage. However, this item is exclusive to Samson and does not apply to any other characters. Lazarus' revived form, Lazarus II, will respawn with this item.